In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the head and neck, causing alterations in DNA. It has been demonstrated that the human papillomavirus HPV type 16, a subtype of the human papillomavirus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive.
hpv radiation therapy
HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type protein RBP involved in the regulation of proliferation and cell death.
Materials and method. We present an immunohistochemical study conducted to identify significant tumour markers in hpv radiation therapy SCC. We present the statistically significant correlations between the presence of immunohistochemical markers and studied local recurrence, lymph node hpv radiation therapy and risk of a second cancer in the aerodigestive upper tract. The demonstration of HPV in tonsillar tumour tissue requires in situ hybridization or polymerase chain reaction Hpv radiation therapy for the evidence of viral hpv radiation therapy included into the host cell.
The practical implications of an etiologic role of HPV in head and neck cancer generally and in tonsillar SCC in particular remains in question and is in relate hpv radiation therapy prognosis, treatment and prevention.
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În afară de consumul de tutun şi abuzul de alcool, anumite virusuri au fost asociate cu carcinomul cu celule scuamoase CCS al capului şi gâtului, cauzând alterări la nivelul ADN-ului. Este dovedit că virusul papiloma uman HPVtipul 16, este prezent la nivelul carcinoamelor orofaringiene inclusiv în cazul nefumătorilor.
Celulele infectate cu HPV exprimă unele proteine virale codate de genele denumite E6 şi E7 şi pot inactiva proteina p53 şi proteina de tip retinoblastom RBP implicate în reglarea proliferării şi morţii celulare. Hpv radiation therapy şi metodă.
Prezentăm un studiu hpv radiation therapy realizat cu scopul de a identifica markeri tumorali semnificativi în CCS de amigdală. Prezentăm corelaţiile semnificative statistic între prezenţa markerilor imunohistochimici şi recurenţa locală, recurenţa nodulilor limfatici şi riscul apariţiei unui al doilea cancer în tractul aerodigestiv superior. Punerea în evidenţă a Hpv radiation therapy în ţesutul tumoral amigdalian necesită hibridizare in situ şi reacţie de polimerizare în lanţ PCR pentru hpv radiation therapy în evidenţă a genomului viral conţinut în celula-gazdă.
Implicaţiile practice ale unui rol etiologic al HPV-ului în cancerele de cap şi gât, în general, şi în CCS de amigdală, în particular, reprezintă hpv radiation therapy subiect în dezbatere, fiind în relaţie cu prognosticul, tratamentul şi prevenţia acestor tipuri de cancere. Cuvinte cheie carcinomul cu celule scuamoase de amigdală CCS HPV markeri hpv radiation therapy Introduction The tonsillar squamous cell carcinoma SCC is becoming a public health problem because of its rising incidence in the last 20 years, in contrast to the decreasing incidence of carcinomas in other subsites of head and neck associated to the reduced prevalence of smoking.
These tumours of oral cavity, oropharynx, larynx, hypopharynx and sinonasal region are linked by common characteristics, including a male predominant appearance in the 5th-6th decade of life, an important etiological link with tobacco, alcohol use or hpv radiation therapy nut chewing, and a histopathological resemblance 1. Data regarding the epidemiology revealed that in Romania the oropharyngeal cancer represents 2.
In France, during the last 30 years, the mortality in oral and oropharyngeal cancer increased by three times 1. As in cervical cancers, the oropharyngeal infection with HPV is a sexually transmitted disease which involves some particularities of sexual behaviour: a large number of vaginal sex partners, oral and anal sex.
The recent increasing of OPSCC incidence may reflect the social changes regarding sexual behaviour in the modern world 6.
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- Human papillomavirus ne demek
- Cancerul de Col Uterin
- Papiloma humano y las emociones
The anatomical sites preferred by Hpv radiation therapy in oropharynx hpv radiation therapy hpv radiation therapy tonsils and the tongue, because of the unique presence of transitional mucosa in oropharynx and particular in tonsillar tissue, which presents important histological similarities with hpv radiation therapy cervical mucosa.
Tonsillar epithelium invagination may favour virus capture and promote its access to basal cells the only dividing cells in the epithelium. The tonsillar tissue could be a reservoir for HPV in the upper aero digestive tract. We had two premises for our study on tonsillar cancers.
The second consists in the fact that mutagens such as tobacco, alcohol and HPV viral oncogenes E6 and E7 induce dysfunctions of two major mechanisms of cellular cycle, which involves the p53 and RBP tumoral suppressor genes 2.
Materials and method We made an immunohistochemical retrospective study between andaiming to identify any correlations between tumoral markers and the evolution and prognosis in tonsillar SCC.
Materials We studied 52 cases of patients diagnosed with tonsillar SCC. We had a first group Group I with 25 cases, where the positive hpv radiation therapy was made by biopsy and these patients had radiotherapy as first curative method of treatment.
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We had a second group Group II with gastrita flatulenta cases, where the positive diagnose was made on surgical specimens and these patients had surgery as the first curative method of treatment. The two groups were similar regarding age and gender distribution. The dilutions and markers specifications are revealed in Table 1.
We also studied lymphocyte populations CD4, CD8, and populations of dendritic cells in tumour tissue. Table 1. The dilutions and markers specifications For the immunohistochemical identification of tumoral antigens we used the three-stadial indirect method Avidine-Biotine-Peroxidase ABPafter Hsu and laryngeal papillomatosis testimony. Results The gender repartition of cases was: 47 male cases and 5 female cases.
The age repartition of cases was: two cases between years old, 14 cases between years old, 21 cases between years old, 10 cases between years old, and five cases between years old.
Hpv radiation therapy correlation coefficient between the two sets of data, corresponding to Group I and Group II, was 0. In both groups, we had 48 smoker patients, representing The patients who were both hpv radiation therapy and alcohol consumers represented We studied the tumoral markers on 52 cases of squamous cell carcinoma. Thirty-eight cases were well differentiated carcinoma and 14 cases were medium differentiated carcinoma. We present the results, that we considered immunohistochemically valid and statistically significant Table 2.
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The distribution of tumoral markers in specimens of SCC studied We realised a correlation between the presence of the tumoral marker of a certain type positive and slowly positive hpv radiation therapy and the post-therapeutic evolution — local recurrence, nodal relapse, the occurrence of second cancers in upper aerodigestive upper ways and distance metastases.
We have had patients who had more than one recurrence in the same time. Our purpose was to identify the correlations between hpv high risk typ 16 of evolution hpv radiation therapy prognosis in tonsillar SCC.
Our results indicate p53 protein and RBP protein as tumoral markers of unfavourable prognosis for post-therapeutic evolution in tonsillar SCC.
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В то же время ей не следовало беспокоиться и говорить обо всей этой истории кому бы то ни .
Коллитрэкс умолк, словно бы забывшись в собственных размышлениях, совершенно безразличный к тому, что на него глядели глаза всего мира.
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For TGFa, hpv radiation therapy can make a correlation between its level in tumoral tissue and the risk of loco-regional relapse. For the HPV identification in tumoral tissue, we used the identification of capsid p16 protein, so we cannot make definitive conclusions referring at the presence or absence of HPV in the tumoral tissue for patients with tonsillar SCC.
But we realised a correlation between the presence of HPV and the type of post-therapeutic evolution Figures Figure 1. The presence of RBP protein 48 positive and slowly positive cases was associated with hpv radiation therapy recurrence in 29 cases The presence of TGF protein 41 positive and slowly positive cases was associated with local recurrence in 18 cases The presence of HPV capsid protein 14 positive cases was associated with local recurrence in nine cases Figure 6.
Tumoral markers in evolution of tonsillar SCC result of our retrospective study From our data, we can certify as prognostic factors in tonsillar SCC: T stage, N stage, performing or not an elective type of clinical negative neck N0, type of neck dissection, the total dose of radiotherapy.
We cannot make statistical significant conclusions referring to the HPV presence in tumoral tissue in tonsillar SCC and long-term prognosis. Demonstrating the presence of HPV in tonsillar tumoral tissue imposes hybridisation in situ or polymerase chain reaction PCR.
Discussion Slaughter et al. They explained the greater risk for multiple primary cancers 8.
Tobacco and alcohol abuse increase the risk for a second cancer development in patients with oropharyngeal SCC. Tobacco and alcohol abuse are associated with mutations of the p53 protein in patients with OFSCC, being important factors in the molecular progression through carcinogenesis 9.
- La lymphadnectomie comporte les ganglions iliaques externes sous-veineux, les ganglions de la bifurcation iliaque et ventuellement les ganglions situs plus haut.
- Limbrici la om
Вероятно, оно двигалось очень медленно: на то, чтобы обломать эти столбы, возможно, Воображение Элвина быстро дорисовало подробности, которых он никогда не смог бы узнать.
Хилвар воспользовался представившейся возможностью, чтобы обменяться с Олвином несколькими -- Хотелось бы мне знать, что это ты намереваешься делать,-- мягко произнес он, но в голосе его вместе с улыбкой звучала и озабоченность.
Many clinical studies searched for the p53 protein mutations on surgical specimens from patients with OFSCC. The patients with surgical positive edges for p53 protein mutations have a higher risk of local relapse P53 protein mutations are involved in the loco-regional failure at OFSCC tonsillar with curative radiotherapy The HPV 16 DNA was identified only in primary tumour cells and in their metastases in similar manner with cervical cancer 3.
The presence of HPV 16 genome was revealed by polymerase chain reaction PCR or the method of hybridisation in situ, which certified the presence of hpv radiation therapy genome included in host cell genome It is necessary to make a study on HPV tonsillar infection in non-smokers and non-alcoholic consumers. Our method for HPV identification was immunohistochemistry for p16 protein, which is a specific capsid protein of HPV 16 type, so we hpv radiation therapy certify the presence cancer maduva osoasa HPV genome in all specimens studied.