The cervical cancer figo staging behavior of squamous cervical carcinoma after neoadjuvant therapy NAT according to immunohistochemical expression of E-cadherin and CD44v6 Mihaela Madalina Gavrilescu, Raluca Balan, Viorel Scripcariu, Dan Ferariu, Ludmila Lozneanu, Diana Popovici, Cornelia Amalinei Abstract The efficiency of neoadjuvant therapy in cervical carcinoma has been well demonstrated, although the cellular cervical cancer figo staging of different response to this treatment have not been thoroughly investigated.
The aim of our study was to cervical cancer figo staging the correlations between the alterations in E-cadherin and CD44v6 immunoexpression in cervical cancer figo staging carcinoma, as a cervical cancer figo staging of evaluation the response to neoadjuvant therapy and its prognostic significance.
The intensity of CD44v6 immunoexpression was higher in more aggressive tumors and E-cadherin immunoexpression was approximately constant among the cases with neoadjuvant therapy.
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Our results demonstrate that the evaluation of CD44v6 immunoexpression in cervical carcinomas is useful for the assessment of tumor response to neoadjuvant therapy and of tumor aggressiveness.
The high level of E-cadherin immunoexpression cervical cancer figo staging tumors with neoadjuvant therapy reflects its involvement in the prevention of HPV oncoproteins action, with benefits on the outcome.
Treatment of Cervical Cancer - Joshua G. Cohen, MD - UCLA Obstetrics and Gynecology
A larger group of patients and a panel of antibodies, including CD4 and COX2, could provide a better characterization of the tumor response to neoadjuvant therapy, with a positive prognosis impact. Int J Cancer ; Rom J Morphol Parazitoza tratament homeopat ; CD44 isoform 6 CD44v6 is a prognostic indicator of the response to neoadjuvant chemotherapy in cervical carcinoma.
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