Cancer genetic markers of susceptibility. Revista Romana de Medicina de Laborator

We also genotyped females and 62 males, who formed the control group. Genotyping results were related to environmental risk factors, smoking habit and diet.

A significantly increased risk for CRC was observed in females cancer genetic markers of susceptibility males with high daily fried red meat intake, carriers of the ArgGln OR 2. Conclusions: In Romanians, the association between the mutated genotypes and uterine cancer pain in legs risk factors modulates the risk for sporadic CRC. Smoking in association with the ArgGln-XRCC1 genetic variation influences the early onset of sporadic colorectal cancer in females.

Since that time, new data have become available, these have been incorporated into the Monograph, and taken into consideration in the present evaluation. Exposure Data 1. Types and ethanol content of alcoholic beverages 1.

Rezumat Introducere: Variațiile genetice, cum ar fi cele care influențează sistemele de reparare a defectelor de replicare a ADN, pot reprezenta factori de susceptibilitate în cancerul colorectal sporadic CCR ca urmare a interacțiunii cu factori de mediu. Am determinat de asemenea, genotipurile pentru femei și 62 bărbațicare au format grupul de control.

Revista Romana de Medicina de Laborator

Rezultatele au fost analizate din punct de vedere al relației cu factorii de cancer genetic markers of susceptibility de mediu, fumatul și dieta. Rezultate: Bărbații fumători purtători ai variațiilor genetice ArgGln, LysGln, MetThr au avut un risc semnificativ crescut de 4.

Un risc semnificativ crescut de a dezvolta cancer colorectal sporadic a fost observat în cazul femeilor și bărbaților cu o dietă bogată în carne roșie prăjită purtători ai variațiilor genetice ArgGln OR 2.

Femeile a căror dietă a inclus cantități mari de carne roșie prăjită au avut un risc semnificativ crescut de a dezvolta timpuriu cancer colorectal sporadic dacă au fost purtătoare a variațiilor genetice ArgGln-XRCC1 OR 5.

Concluzii: În cazul populației de origine română, asocierea genotipurilor mutante cu factori de mediu modulează riscul pentru CCR sporadic. La femei, fumatul în asociere cu variația genetică ArgGln-XRCC1 influențează debutul timpuriu al cancerului colorectal sporadic.

Smoking exposure as a risk factor for prevalent and recurrent colorectal adenomas. Cancer Epidemiol Biomarkers Prev. Google Scholar 2. Prevalence of colorectal neoplasia in smokers.

Personal Habits and Indoor Combustions.

Am J Gastroenterol. DOI: Cigarette smoking and other behavioral risk factors for recurrence of colorectal adenomatous polyps. Cancer Causes Control. A mechanistic study of colon cancer growth promoted by cigarette smoke extract.

Hereditary cancers and genetic testing: Mayo Clinic Radio

Eur J Pharmacol. Risk and protective factors for development of colorectal polyps and cancer Bulgarian experience.

1. Exposure Data

Google Scholar 7. Lampe JW. Diet, genetic polymorphisms, detoxification and health risks. Altern Ther Health Med. Google Scholar 8.

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