Cancer genetic and environmental factors.

Selected References These references are in PubMed.

cancer genetic and environmental factors

This may not be the complete list of references from this article. Oxygen activation by cytochrome P Annu Rev Biochem.

Hereditary Colorectal Cancer: Laura Valle · | Books Express

The molecular biology of cytochrome Ps. Pharmacol Rev.

Cancer biology part 5 Genes associated with cancer

The P superfamily: update on new sequences, gene mapping, and recommended nomenclature. DNA Cell Biol.


Evolution of cytochrome P proteins. Mol Biol Evol. Evolution of the P gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation. Trends Genet. Oxidation of toxic and carcinogenic chemicals by human cytochrome P enzymes.

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Chem Res Toxicol. Constitutive and inducible expression of human cytochrome PIA1 in yeast Saccharomyces cerevisiae: an alternative enzyme source for in vitro studies. Biochem Biophys Res Commun. The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.

  1. Cancerul – de la etiologie la abordări terapeutice
  2. Rostliny paraziti
  3. Negreş Simona, As.

J Pharmacol Exp Ther. Expression of a human liver cytochrome P protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae. Mol Pharmacol.

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Identification of a new variant CYP2D6 allele lacking the codon encoding Lys possible association with the poor metabolizer phenotype.

cancer genetic and environmental factors

A tobacco smoke-derived nitrosamine, 4- methylnitrosamino 3-pyridyl butanone, is activated by multiple human cytochrome Ps including the polymorphic human cytochrome PD6.

Mutagenic activation of 2-aminomethylimidazo[4,5-f]quinoline by complementary DNA-expressed human liver P Cancer Res. J Biol Chem. Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process. Mutat Res.

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Induction of hepatocellular carcinoma in nonhuman primates by chemical carcinogens. Cancer Detect Prev.

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Five of 12 forms of gemoderivate pentru oxiuri virus-expressed human hepatic cytochrome P metabolically activate aflatoxin B1. Assay for gene mutation in a human lymphoblast line, AHH-1, competent for xenobiotic metabolism.

cancer genetic and environmental factors

A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing. Molecular genetics of the debrisoquin-sparteine polymorphism.

Cancer – from etilogy to therapeutic approaches

Clin Pharmacol Ther. Relevance of metabolic polymorphisms to human cancer genetic and environmental factors evaluation of epidemiologic evidence.

Identification of a human liver cytochrome P homologous to the major isosafrole-inducible cytochrome P in the rat. Purification cancer genetic and environmental factors characterization of the human liver cytochromes P involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism.

Identification and quantitation in human liver of cytochromes P analogous to rabbit cytochromes P forms cancer genetic and environmental factors and 6. Metabolism of N-nitrosodialkylamines by human liver microsomes.