Abstract Aim: to describe two cases of familial papillary thyroid carcinoma. Material and methods: patients were investigated by fine needle biopsy, MRI imaging and tumor biopsy, first papillary thyroid carcinoma variants and histological examination of colonic and thyroid tumors first case and histological examination of thyroid tumor second case. Results and discussion: case presentation: first case, 68 years old man had a colonic polyposis attenuated form with only a few polyps and a thyroid nodule.
Nicolau Institute of Virology, Bucharest, Romania. Introduction: In human cancer cells DNMTs are responsible for both de novo and maintenance methylation of tumor suppressor genes.
Design: 49 patients aged 1082 years hospitalized for thyroidectomy were included between January and July The inclusion criterion was patients with thyroid papillary thyroid carcinoma variants with indication for surgery and the exclusion criteria were: hyperthyroidism, medullary thyroid carcinoma, thyroid metastasis, other thyroid tumors, and anaplastic thyroid carcinoma. Patients were divided into three groups.
Group 1: 26 subjects with papillary thyroid carcinoma. Group 2: papillary thyroid carcinoma variants patients with follicular adenoma.
Group 3: nine patients with multinodular goiter. Group 1 was divided in: Group papillary thyroid carcinoma variants.
Total RNA was isolated from tissues and reverse transcribed. Double normalization was performed related to gene expression levels found in peritumoral tissues.
SPSS 18 program was used to perform statistical analyze. The comparison of cancer subtypes did not reveal significant differences for DNMT1.
DNMT1 expression did not correlate with tumor stage, tumor multifocality, capsular, vascular or lymphatic invasion or with metastasis. Conclusion: DNMT1 is not overexpressed in papillary thyroid carcinoma and does not correlate with tumor stage, tumor multifocality, capsular, vascular or lymphatic invasion or with metastasis.