Papillary thyroid cancer hemithyroidectomy


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Nicolau Institute of Virology, Bucharest, Romania. Introduction: In human cancer cells DNMTs are responsible for both de novo and maintenance methylation of tumor suppressor genes.

papillary thyroid cancer hemithyroidectomy

Design: 49 patients aged 10–82 years hospitalized for thyroidectomy were included between January and July The inclusion criterion was patients with thyroid nodules with indication for surgery and the exclusion criteria were: hyperthyroidism, medullary thyroid carcinoma, thyroid metastasis, other thyroid tumors, and anaplastic thyroid carcinoma. Patients were divided into papillary thyroid cancer hemithyroidectomy groups.

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Group 1: 26 subjects with papillary thyroid carcinoma. Group 2: 14 patients with follicular adenoma.

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Group 3: nine patients with multinodular goiter. Group 1 was divided in: Group 1. Total RNA was isolated from tissues and reverse transcribed. Double normalization was performed related to gene expression levels found in peritumoral tissues.

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SPSS 18 program was used to perform statistical analyze. The comparison of cancer subtypes did not reveal significant differences for DNMT1.

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DNMT1 expression did not correlate with tumor stage, tumor multifocality, capsular, vascular or lymphatic invasion or with metastasis. Conclusion: DNMT1 is not overexpressed in papillary thyroid carcinoma and does not correlate with tumor stage, tumor multifocality, capsular, vascular or lymphatic invasion or with papillary thyroid cancer hemithyroidectomy.

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