Neuroendocrine cancer markers, Cromogranina A – marker pentru tumorile neuroendocrine - Cancer


Cromogranina A – marker pentru tumorile neuroendocrine - Cancer

One of the major tools to evaluate this type of pathology is the neuroendocrine markers as chromogranin A, serotonin, urinary 5-hydroxy indolacetic acid, and neuron neuroendocrine cancer markers enolase.

They change related to the disease progression, regardless therapy. Some of the drugs that are neuroendocrine cancer markers for NETs as somatostatin analogs for example octreotide might interfere with glucose metabolism.

We analyzed in a retrospective study of 2 years the dynamic of the NET markers and neuroendocrine cancer markers glycemia profile. Material and Methods.

Este o boala neoplazica avand ca neuroendocrine cancer markers de plecare celulele sistemului endocrin difuz SED. Tumorile carcinoide pot fi localizate oriunde la nivelul tubului digestiv, dar cel mai frecvent le gasim in jurul valvei ileocecale. Pot fi asimptomatice sau pot genera simptome obstructive.

All the patients had at least one assay per year. The dose of octreotide varied from 20 to 50 mg, monthly.

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The fasting glucose insignificantly changed from baseline after 2 years. No new case of diabetes was registered.

One case of known diabetes needed insulin but interferon therapy was also added during this time period. The chromogranin A had sustained high values for all the 9 cases, marking the disease progression.

Revista Romana de Medicina de Laborator

The neuron specific enolase significantly increased, and the serum serotonin as well as the 5HIIA was much higher in 2 cases with aggressive carcinoid symptoms. The NET markers and the glucose metabolism are most useful tools in the management of NETs, yet they are not correlated.

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Rezumat Tumorile neuroendocrine NET sunt mult mai frecvente în ultimele decade. Unul din intrumentele majore de evaluare neuroendocrine cancer markers această patologie este reprezentat de dozarea markerilor neuroendocrini precum cromogranina A, serotonina, acidul 5-hidroxi indolacetic urinar şi enolaza neuronal specifică.

Aceştia se schimbă cu progresia tumorală, indiferent de terapie. O parte din medicamentele folosite în NET precum analogii de somatostatin de exemplu, octreotid interferă cu metabolismul glucozei.

Am analizat într-un studiu retrospectiv de-a lungul a 2 ani dinamica markerilor NET şi profilul glicemic. Material si metode. Toţi pacienţii au avut cel puţin o evaluare pe an.

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Doza de octreotid a variat de la 20 la 50 mg lunar. Glicemia s-a modificat nesemnificativ de la bază după 2 ani.

  • Limitări Ce este cromogranina A?
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Nu s-a înregistrat nici un caz nou de diabet. O pacientă a necesitat insulină pentru diabetul preexistent dar între timp s-a adaugat şi terapie cu interferon Cromogranina A a avut valori mari sustinute pentru toate cele 9 cazuri, sugerând progresia bolii. Enolaza neuronal neuroendocrine cancer markers a crescut semnificativ iar serotonina serică şi 5HIIA au crescut considerabil în 2 cazuri cu simptome severe de sindrom carcinoid.

Markerii NET şi metabolismul glucidic sunt instrumente foarte utile in managementul tumorilor neuroendocrine, totusi neuroendocrine cancer markers nu se coreleaza.

Ce este cromogranina A?

Cuvinte cheie: cromogranina A ; tumora neuroendocrina ; serotonina References 1. Neuroendocrine cancer markers tumors. Endocr Relat Cancer. DOI: Oberndorfer S.

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Cromogranina A – marker tumoral pentru tumorile neuroendocrine

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Artikelempfehlungen Abstract The neuroendocrine tumors NETs are more frequent during the last decades. One of the major tools to evaluate this type of pathology is the neuroendocrine markers as neuroendocrine cancer markers A, serotonin, urinary 5-hydroxy indolacetic acid, and neuron specific enolase.

Treatment of malignant midgut carcinoid tumours with a long-acting somatostatin analogue octreotide. Acta Oncol.

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