Metastatic cancer in brain, Female Urethral Carcinoma
The patient initially received palliative chemotherapy with Paclitaxel, discontinued due to allergic reactions, and targeted therapy with Herceptin.
BM were treated with antalgic radiotherapy and bisphosphonates. After metastatic cancer in brain occurrence of secondary brain lesions, the patient underwent palliative whole-brain radiotherapy WBRT and systemic treatment with Capecitabine and Lapatinib from February In FebruaryLapatinib was replaced with Trastuzumab emtansine, after the approval of this drug in Romania.
The authors report this case in order to illustrate the importance of the multidisciplinary management of BM that had substantially improved the neurological symptoms and survival in this patient.
Early recognition and appropriate therapy of breast cancer is imperative as it may be crucial for the outcome. Brain metastases in HER2-positive breast cancer: the evolving role of lapatinib.
Debut fulminant într-un sindrom cerebro-metastic- prezentare de caz. Source: Romanian Journal of Neurology.
Yarden Y. The EGFR family and its ligands in human cancer: signaling mechanisms and therapeutic opportunities. Europ J Cancer 37 suppl 4 : S3-S8.
Metastatic behavior of breast cancer subtypes. J Clin Oncol, ; Givens ML, Luszczak M.
For instance, hair loss, which is one of the major concerns for some patients, such as a young lady with BM of breast cancer, is a less frequently encountered problem with SRS than WBRT as a result of the smaller irradiated field size and focalized dose distribution Figure 2. All the aforementioned advantages of SRS are provided by utilization of multiple convergent narrow beams to deliver high dose focal irradiation in a single fraction by using multiple cobalt sources, linear accelerators or cyclotrons 37,
Breast disorders: a review for emergency physicians. J Emerg Med.
Capecitabine therapy of central nervous system metastases from breast cancer. J Neurooncol ; Prognostic significance of human epidermal growth factor metastatic cancer in brain positivity for the development of brain metastasis after newly diagnosed breast cancer.
J Clin Oncol ; 24 36 : Brain metastases: the HER2 paradigm. Clin Cancer Res ; Breast cancer brain metastases: a year review of treatment outcomes.
Discussion: A small number of patients with lung cancer has a limited number of extra-thoracic metastases oligometastases. Some of these patients may benefit from resection of both primary and metastatic sites, in addition to systemic treatment, with the goal of increasing survival and achieving curability. Retrospective studies show that patients with oligometastatic lung cancer can achieve long-term survival if the surgical treatment achieves complete resection of the primary and all evident metastatic sites. Adrenal and brain metastases deserve special attention as they are well documented in literature. Adrenal metastases are believed to be a consequence of lymphatic dissemination rather than hematogenous spread.
Breast ; Brain metastases of breast cancer. Breast Dis.
Causes of metastatic cancer in brain in patients with stage 0-II breast cancer. Treatment and prognosis of brain metastases from breast cancer. Lancet Oncol ; Ann Oncol ; An overview on screening for breast cancer awareness in Romanian general population.
Iasi ; 3 :