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The patient initially received palliative chemotherapy with Paclitaxel, discontinued due to allergic reactions, and targeted therapy with Herceptin.

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BM were treated with antalgic radiotherapy and bisphosphonates. After the occurrence of secondary brain lesions, the patient underwent palliative whole-brain radiotherapy WBRT and systemic treatment with Capecitabine and Lapatinib from February In FebruaryLapatinib was replaced with Trastuzumab emtansine, after the approval of this drug metastatic cancer details Romania.

The authors report this case in order to illustrate the importance of the multidisciplinary management of BM that had substantially improved the neurological symptoms and survival in this patient.

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Early recognition and appropriate therapy of breast cancer is imperative as it may be crucial for the outcome. Brain metastases in HER2-positive breast cancer: the evolving role of lapatinib.

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Europ J Cancer 37 suppl 4 : S3-S8. Metastatic behavior of breast cancer subtypes.

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J Neurooncol ; Prognostic significance of human epidermal growth factor receptor positivity for the development of brain metastasis after newly diagnosed breast cancer.

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Lancet Oncol ; Ann Oncol ; An overview on screening for breast cancer awareness in Romanian general population. Iasi ; 3 :

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