Human papillomavirus bench to bedside. Oncolog-Hematolog Nr. 35 (2/) by Versa Media - Issuu


PCMC is more frequently found in males and it usually appears between the ages of 50 and Mendoza and Hedwig made the first contemporary description qeshte virusi this eyelid-located tumour. Taking into consideration the rarity of this tumour, a diagnosis of certitude is difficult to establish until further human papillomavirus bench to bedside are made, in order to eliminate the primary malignant tumour with visceral location with mucine production that can metastasize at cutaneous level, as for example that of breast, gastrointestinal tract, lung, kidney, ovary, pancreas, or prostate.

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The metastatic lesions that originate from the breast or colon are prone to mimic the cutaneous mucinous carcinoma 4. There is no specific clinical evidence for this type of tumour, as its appearance varies from one patient to another. The first clinical impression is that of a cyst, basal cell carcinoma, keratoacantoma, nevus, apocrine hidrocystoma, another location primary tumour metastasis and in certain circumstances the clinical differentiation includes vascular lesions as those found human papillomavirus bench to bedside the Kaposi sarcoma 5.

The human papillomavirus bench to bedside describe human papillomavirus bench to bedside slow evolution, stretched over several years, of the lesion, completely asymptomatic. Occasional, the very old tumours or the very aggressive ones can invade the adjacent structures 6. The slow, benign evolution theory of this tumour is correlated with mucine production which is linked to its high celular differentiation grade.

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Moreover, the presence of big mucus accumulations can serve as physical barrier in tumour extension, compressing the tumour stroma, slowing the growth, inhibiting the DNA synthesis and decreasing the angiogenesis rate 8. Although the clinical presentation of PCMC is non-specific, the histopathological exam is pathognomonic.

Usually, the tumour is well delimitated, with small accumulations or tubules of epithelial cells which float in mucine.

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Mucine is separated by fine collagen fibres septa and is positive to PAS stain, mucicarmina, alcian blue at a pH of 2. Mucine, same as sialomucine, was characterized as sialidase-labile.

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The cells are small, human papillomavirus bench to bedside, vacuolated with eosinophilic cytoplasm. The cellular pleomorfism and the 1.

Primary mucinous carcinoma, J Dermatolog Surg Oncol Primary mucinous carcinoma of the skin with metastases to the lymph nodes. Am J Dermatopathol ; Human papillomavirus bench to bedside of sweat glands, report of 60 cases. Arch Pathol Lab Med ; Smith CC Metastazing carcinoma of the sweat-glands.

Br J Surg43 Primary mucinous carcinoma of the skin: A population based study. Int J Dermatol. Further investigations are necessary in order to eliminate the skin human papillomavirus bench to bedside 7,8.

The immunohistochemistry exam can facilitate the differential diagnoisis.

PCMC cells remain positive for CK 7 and negative for CK human papillomavirus bench to bedside, the same occurs for the mucinous adenocarcinoma of the breast, but in the case of the mucinous colorectal adenocarcinoma CK 7 is negative and CK 20 is positive.

This way, the absence of CK 20 excludes skin metastases originated from the mucinous colorectal adenocarcinoma. Another CK 7 positive and CK 20 negative tumours, as the adenocarcinoma of the lung or of the gallbladder, can also produce skin metastases. These can be excluded using systemic suplimentary investigations and another types of immunohistochemistry specific colorations 9. Because the skin metastases originating from breast and lung can express the p63 protein, the use of this expression remains controversial and so, further investigations are mandatory.

Quereshi et al. In a complex analysis of the skin metastasis, Brownstein et al. The treatment of PCMC imposes local surgical excision. Because of the high local relapse rate, the proper excision with oncological safety margins at least human papillomavirus bench to bedside cm is recommended.

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