Hpv positive base of tongue cancer, Tratamentul carcinoamelor de planşeu oral anterior


Frequently, a mandible resection is required in order to hpv positive base of tongue cancer safe oncologic margins.

Tratamentul carcinoamelor de planşeu oral anterior

The prognosis is good, with a higher overall survival rate than in other oral malignancies. Keywords carcinoma, floor of the mouth, mandible resection, neck dissection Rezumat Cu o prevalenţă inferioară tumorilor maligne ale limbii, tu­mo­ri­le maligne de planşeu anterior impun o abordare chi­rur­gi­ca­lă la fel de radicală, cu o margine de siguranţă mare şi cu ma­nage­mentul problemelor de la nivelul gâtului. Datorită lo­ca­li­ză­rii lor anterioare, sunt mai uşor de diagnosticat, iar pa­cien­tul se prezintă şi în stadii incipiente, nu doar în stadii tar­di­ve.

Frecvent, este necesară rezecţia mandibulei, pentru a obţine margini de siguranţă oncologică.

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Prognosticul este bun, cu o supravieţuire generală mai mare decât în cazul altor ma­lig­ni­tăţi orale. Cuvinte cheie carcinom planşeu oral rezecţie de mandibulă hpv positive base of tongue cancer cervicală Introduction Oral cancer is the most encountered tumor in head and neck breast cancer genetic counseling. It usually affects male patients in their 6th decade of life 1a possible explanation for this gender imbalance being related to smoking and drinking, which are more frequent in men.

It is age-related, the 5th and 6th decade of life seems to be the most encountered, but in the last years there is a growing tendency in younger adults years old, below Also, strong relations are emerging concerning HPV infection and oral carcinoma, especially the 16th subtype seems to be involved in cancer pathology 2. What is sure is that HPV in oncologic patients is a negative hpv positive base of tongue cancer factor.

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Diagnosis Before developing cancer tumors, patients can present with mucosal lesions such as leukoplakia, erythroplakia or a combination of the two. Sometimes the onset is missed by the doctor or the patient, as it can mimic numerous benign conditions, but as it develops, the signs of malignancy are more pronounced solid mass, infiltrative, ulcerated lesionand it will generally present in one hpv positive base of tongue cancer the two main stages: exophytic or endophytic.

For radiological assessment of the cancer patients, the most implied methods are CT scanning for bony invasion and MRI for muscles involvement and to accurately determine the cervical metastasis. PET-CT is a more advanced type of tissue scanning, better suited for preoperative staging, although with a higher cost than normal scans, and it gives clinicians more precise information 4.

Cervical metastasis, due to a higher in­take of glucose, can be easier hpv positive base of tongue cancer, as many PET diagnosed occult metastases proved to be malignant at the histological HP report, but sometimes negative masses in PET scan were also found to be positive at the HP examination.

Treatment of anterior floor of the mouth carcinomas

It is not a total bullet proof investigation, but is a powerful tool when dealing with cancer patients. The treatment implies a surgical phase and adjuvant oncological therapy. Even late stages can be surgically cured and the remaining defects reconstructed with the aid of free flaps. The prognosis depends on the negative resection margins 6thus having a safe oncological margin of more than 5 mm and lack of margin dysplasia. Because there are situated hpv positive base of tongue cancer the proximity of the lingual cortex, in many cases an en bloc mandible resection should be performed even in earlier stages.

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Usually, a continuity sparing resection is performed; a segmental resection in moderate stages would not grant an extra benefit regarding the oncologic prognosis, but it will inflict a greater impairment for the patient due to muscle attachment loss 7. In early stages, the cervical metastases are not that frequent, but in advanced tumors the neck must be carefully checked. When the diagnosis is N0 for cervical metastasis, depending on the tumor pattern, an elective neck dissection can be performed SOH dissectionconsidered to have the same benefits as a radical dissection 8.

Most of the cervical metastases are found in the first three lymphatic levels, so a SOH neck dissection will hpv positive base of tongue cancer a proper outcome. Adjuvant radiotherapy and chemotherapy are performed when positive margins are found, or the tumor has a vascular or neural hpv positive base of tongue cancer.

Regarding the cervical metastases, adjuvant therapy is applied when there is a positive carcinoma involvement, irrespective of capsule integrity 9.

Aim: To implement the HPV genotyping method of fresh head and neck cancer samples in our laboratory. More than half of the patients recognized being chronic alcohol and tobacco users. Conclusions: The genotyping method was validated according to kit instructions. To get a general idea on the prevalence of HPV genotypes in head and neck cancer in our region we tested a very small number of samples. Ferlay J, Soerjomataram I et al.

Radiotherapy as first therapy is employed in advanced stages where surgical cure cannot be performed, as a palliative treatment or for tumor conversion. Case 1 Figure 1. Case 1. Above — anterior FOM tumor. Below left — CT scan, no bony invasion. Below right —month check up, no relapse A year-old patient hpv positive base of tongue cancer for a floor of the mouth FOM swelling, with a 3-month duration. The patient had an ulcerated fixed tumor mass with irregular shape and borders, with pain on palpation, without any clinical signs of cervical metastasis.

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A hpv positive base of tongue cancer was taken squamous carcinoma and an en bloc resection with marginal mandible resection was performed, hpv positive base of tongue cancer primary closure. At the month follow-up, no sign of relapse was noted locally and cervical.

Хотя Галактика и была опустошена Безумцем, ресурсы Империи все еще были огромны и дух не сломлен. Со смелостью, которой мы можем лишь восхищаться, великий эксперимент был возобновлен и начались поиски ошибки, вызвавшей катастрофу.

Case 2 Figure 2A. Case 2. Above left — anterior FOM tumor. Right — cervical metastasis Figure 2B. Above — intraoperative photo: neck dissection. Below — intraoperative photo with the reconstructed defect with lingual flap A year-old hpv positive base of tongue cancer was sent to our department by an ENT colleague for an anterior FOM mass with cervical lymph node involvement.

CT scan showed an anterior FOM tumor without bony invasion, but in close contact with the mandible, and left cervical metastasis. A biopsy was performed — squamous cell carcinoma.

An intraoral en bloc resection was performed with mandible partial resection and neck dissection, primary closure with lingual flap.

Adjuvant oncologic treatment was performed.

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The patient is tumor-free after 18 months. Case 3 Figure 3. Case 3. Below left — anterior FOM tumor. Below centre — the defect. Below right — intraoperative photo with the reconstructed defect with lingual flap A year-old patient was sent to our department by the general practitioner for an anterior FOM mass, recently developed.

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The CT scan showed an anterior FOM mass, with muscle involvement, without bone invasion, without node metastasis. A pull-through approach was performed, with en bloc resection, with mandible marginal resection, bilateral SOH neck dissection, primary closure with lingual flap.

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The patient is tumor-free after 12 months. Conclusions Early stage anterior FOM carcinoma without lymph node involvement can be safely managed with intraoral surgical resection and primary closure cancerul cu metastaze reconstruction with local flaps.

In late disease, the approach is combined oral and cervical, or cervical by pull-through procedure, addressing the tumor and the lymph nodes. Adjuvant oncologic treatment is performed, respective of node involvement and tumor pattern and margins. Conflict of interests: The authors declare no conflict of interests.

hpv positive base of tongue cancer

Criteria to rationalize population screening to control oral cancer. Oral Oncol. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev.