Project Director: Prof. Surgical tumor resection and liver transplantation, remain the only curative modalities for HCC, but recurrence rate is still high. In light of the dismal clinical outcome of this neoplasm, the development of effective systems that can predict the likelihood of recurrence is much needed.
Classically, two hepatocellular cancer medical term models of carcinogenesis have been debated: the stochastic model and the hierarchical model.
ARFI: from basic principles to clinical applications in diffuse chronic disease—a review
The hierarchical model or cancer stem cell CSC model, postulates that a single CSC gives rise to a hierarchic organization containing varied downstream descendants, proliferates extensively, and initiates tumors at high frequency.
The role of liver stem cells in HCC carcinogenesis has been illustrated experimentally. Our project will allow the identification of new diagnosis and prognosis markers for HCC, potentially adding novel markers to the molecular classifications.
Impact, relevance, applications. The impact of the project will be assessed by: The clinical impact hepatocellular cancer medical term prediction of early recurrence leading to more aggressive follow-up after surgical therapy; potential identification of new molecular markers for targeted therapy; selection of patients for LT that have a low risk for recurrence according to identified significant markers. The social impact — increase of the quality of life and survival of HCC patients; increase of the efficacy of treatment methods by their applicability in early stages; allow the best use of the scarce number of liver allografts available The economic impact — decrease of the costs of medical assistance by optimizing the diagnostic and therapeutic act.
Current anticancer drugs kill differentiated cancer cells and cause a reduction in tumour mass. However, the cancer often recurs after treatment and this can be attributed to the presence of Hepatocellular cancer medical term. Current research is now looking into a new generation of anticancer drugs or therapies that will selectively and specifically destroy various populations of CSCs while leaving the normal stem cell population unharmed, to allow hepatocellular cancer medical term the complete regeneration of normal hepatocellular cancer medical term.
This is of even more importance in liver cirrhosis setting as are the majority of HCC patients that undergo resection.
Other potential application is the identification of a gene expression signature that could effectively predict early recurrence of HCC independent of microarray platforms and cohorts, and provide novel biological insights into the mechanisms of tumor recurrence in HBV and HCV related HCC.
Project Team: Project Director: Prof. Gheorghe Liana Team Members: Prof. Irinel Popescu, Prof.
Management pattern of hepatocellular carcinoma at two tertiary centers in Romania. Recurrent hepatitis c following liver transplantation in the romanian transplant program — treatment and outcome.
Recipi ent IL28B gene polymorphism and sustained viral response in Romanian patients with recurrent hepatitis C following liver transplantation.
Quantitative gene expression of liver progenitor cells specific genes in hepatocellular cancer medical term treated hepatocellular carcinoma. Impact of cytolysis after transarterial chemoembolization for hepatocellular carcinoma — a single center experience. Which oligosaccharide to use for minimal hepatic encephalopathy in liver cirrhosis patients — oligofructose enriched-inulin or lactulose?
Citas por año
J Hepatol ; 60 1 : S1:S Risk factors for 3 months mortality following liver transplantation in Romanian Transplant Program. Risk factors for death in cirrhotic patients with non-malignant portal vein thrombosis on the waiting list for liver transplantation.
J Gastrointestin Liver Dis Liver stiffness measurement is influenced by type of autoimmune-related liver disease. Both cholestasis and portal hypertension predicted by hepatocellular cancer medical term stiffness, but not by spleen stiffness.
Improved overall mortality on the Romanian waiting list for liver transplantation. Predictors of short-term post-liver transplant mortality in the Romanian Transplant Program. S Iacob.
Screening for hepatocellular carcinoma. Iasi J Gastrointestin Liver Dis ; 24 Suppl 1. Oral Presentation.
The small bowel is currently the most difficult to examine segment of the digestive tract due to its distal location from both natural orifices usually used during routine digestive endoscopy. However, examining it is vital as an important number of pathologies, most of them malignant and thus with vital implications for the patient, reside at this level. All these methods were either too intrusive or did not provide sufficient data for an accurate diagnostic.
Hepatocyte reprogramming in a stem-cell-like phenotype. A potential mechanism of hepatocarcinogenesis. Staging of hepatocellular carcinoma in patients with liver cirrhosis enrolled in a screening program. Transarterial chemoembolization in hepatocellular carcinoma — a single center experience from Romania.
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Hepatocyte telomerase expression in chronic liver disease and primary liver tumors — arguments for hepatocyte reprogramming. Journal of Tranlational Medicine and Research Published Abstract in Gastroenterology Published Abstract in Transplantation Iacob S, Cicinnati V.
M, Rebmann V, Horn P.
A, Kabar I, Schmidt H. H, Beckebaum S. Published Abstract in Hepatology International Tranplantation Suppl 98 Gastroenterology ; 5. Poster Presentation.
RECONSIDERING STATINS-CURRENT VIEW
Gastroenterology Risk factors associated with overall and bleeding-related mortality in patients with portal vein thrombosis on the waiting list for liver transplantation. New organ allocation score predicting both pre and post-transplant survival in the romanian national transplant program. Digestive Disease Week Post-liver transplant fibrosis allograft progression is associated with increased hepatocellular cancer medical term of soluble NKG2D ligands.
Journal of Hepatology Single nucleotide polymorphisms of CYP3A subfamily and p-glycoprotein influence pharmacokinetics of once-daily extended release tacrolimus in liver transplant recipients. Transplant International Efficacy of new antivirals in liver transplant recipients with severe recurrent hepatitis C in a large volume transplantation centre in a limited resource setting. Significance hepatocellular cancer medical term liver enriched transcription factors as molecular markers for hepatocellular carcinoma recurrence after a potentially curative treatment.