Selective ex vivo photothermal nano-therapy of solid liver tumors mediated by albumin conj Selective ex vivo photothermal nano-therapy of solid liver tumors mediated by albumin conjugated gold nanoparticles. Biomaterials ; Our incentive to develop an original model hepatocellular cancer in vivo living liver cancer sprang from the ethical drawbacks that hindered the assessment of the selective character and the therapeutic capacity of these nano-biosystems in cancer hepatocellular cancer in vivo.
Ex vivo-perfused liver specimens were obtained from hepatocellular carcinoma patients hepatocellular cancer in vivo to the surgical technique of transplantation. Albumin bound to GNPs was inoculated intra-arterially onto the resulting specimen and determined the specific delivery of the nano-bioconjugate into the malignant tissue by means of the capillary bed.
The extent of necrosis was considerable following hepatocellular cancer in vivo therapy and at the same time surrounding parenchyma was not seriously affected.
The selective photothermal ablation of the malignant liver tissue was obtained after the selective accumulation of BSA bound to GNPs into tumor cells following ex-vivo intra-vascular perfusion.