Cervical cancer during pregnancy

Stamatian Secretar {tiin]ific Comitet {tiin]ific Interna]ional Conf. Ona Prof. Suciu Prof. Bulent Tiras Turcia Prof. Zervoudis Grecia Secretari de redac]ie Prof. Valentin Friptu Rep. Moldova Prof. Vl d reanu Prof. Feride Sahin Cervical cancer during pregnancy Prof.

Nanu Prof. Cervical cancer during pregnancy Conf. Cernea Prof. Onofriescu Conf. Anca Stãnescu Reproducere asistat Oncologie ginecologic Prof. Marinescu Prof. Peltecu Prof. Szabo Planificare familial Endocrinologie ginecologic Prof. Cr iu] Conf.

Evaluarea colposcopică şi managementul infecţiei cu HPV în sarcină

Manuela Russu Conf. Neagu Conf. Anca Patologie obstetrical Prof. Anastasiu Imagistic Prof. Dumitrache Prof. Tic Chirurgie endoscopic Conf. Craina Neonatologie Prof. Silvia Stoicescu Conf. Chitulea Prof. Goidescu, D. Eniu, F. Stamatian Oral pathology and its consequences on the maternal-fetal outcome in pregancy a review of the literature Adriana Objelea, Georgiana Nemeti, F. StamatianGabriela Caracostea Original article Chlamydia infection a linkage to preeclampsia development B.

Vinereanu, Monica Mihaela Cîrstoiu Successful pregnancy outcome after laparoscopic myomectomy for a large myoma in a patient with previous uterine artery embolization and C-section L. Pirtea, Cristina Secoşan, D. Varianta electronica pentru tiparire prin e-mail: revistaog yahoo.

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Tabelele vor fi numerotate cu cifre latine, iar graficele, schemele, fotografiile cu cifre arabe. Abonamente anuale Membrii Societ ]ii de Obstetric -Ginecologie Semn tura Gynecologic cancers are the most common malignancies diagnosed during pregnancy, and by their location and the impact of their treatment on fertility are becoming a very important issue. The treatment of cancer during pregnancy is a therapeutic challenge because of the necessity of a hpv herpes verschil team and the lack of information or conflicting data regarding the impact of treatment on embryo- fetal development.

Rezumat: Consideraţii generale despre cancerele ginecologice în sarcină Diagnosticul de cancer în sarcină în ultimii ani a cunoscut o creştere continuă, acest lucru datorându-se şi amânării primei sarcini din considerente sociale şi profesionale. Cancerele ginecologice sunt cele mai frecvente afecţiuni maligne diagnosticate în sarcină, iar prin localizarea acestora şi impactul tratamentului asupra fertilităţii devin o problemă foarte importantă.

Dacă în trecut în momentul diagnosticării unei forme de cancer în sarcină recomandarea era de avort terapeutic şi începerea tratamentului oncologic, în prezent există o tendinţă tot mai mare de a ţine cont de dorinţa pacientei şi păstrarea a sarcinii dacă este posibil. Tratamenul cancerului în sarcină este o provocare terapeutică, datorită necesităţii unei echipe multidisciplinare şi a lipsei de informaţii sau a datelor contradictorii privind impactul tratamentului asupra dezvoltării embrio-fetale.

Eniu, e-mail: tudor. Am J Obstet Gynecol Gynecologic cancers are the the pregnancy cervical cancer during pregnancy an aggravating prognostic factor, most common malignancies diagnosed in pregnancy, according to some studies[13]. Most women diagnosed with cancer in General aspects of the imaging pregnancy, will experience a high amount of emotional diagnosis of gynecologic cancers in pregnancy distress, which can lead to long-term psychological sequelae.

This stress is due to the fear of death and 1. For an optimal therapeutic conduct it is 2. MRI can also be used throughout the always mouth warts go away need for a multidisciplinary team that pregnancy, but contrast media should be avoided as includes an obstetrician, an maternal-fetal specialist, much as possible as possible [1, 13].

Contrast an oncologist, a cancer surgeon, a neonatologist, a substances using iodine or gadolinium, even in the specialist in pharmacology, but also a psychologist absence of proven major teratogenic effects can be and a social worker [12].

The therapeutic conduct used only if absolutely necessary and if all other should take into consideration the desire of women diagnostic methods have been exhausted[1]. The sentinel node tehnique, with cancer type, stage of disease, and the possibility of Technetium 99 can be used with caution if other keeping the current pregnancy[12]. Mammography - can be used safely 1. Cervical Cytology - there is no after the first trimester, using abdominal shield difference between cytobrush and other harvesting protection [17],but sometimes because of the high methods regarding the complications bleeding, vascularization of the breast due to pregnancy miscarriages [22].

These mental retardation, carcinogenic cervical cancer during pregnancy, but these side cellular changes induced by pregnancy can cause effects are depending on the dose of radiation, the large cells with large nuclei and these cytological anatomical region examined and cervical cancer during pregnancy important, the aspects can be misinterpreted as dysplastic cells [4].

Cervical cancer during pregnancy to radiation with a higher 2. Cervical biopsy. The biopsy will be indicated only when the suspicion of invasion is high, and it will be General aspects cervical cancer during pregnancy tumor performed preferably into the second trimester when markers in pregnancy the risk of bleeding and miscarriage are lower.

Cervical Cancer Awareness Week - Canadian Cancer Society

The factor that If bleeding occurs, it may be controlled by mostly limits their clinical utility is the lack of specificity using local application of silver nitrate solution or and sensitivity, because most tumor markers are Monsel solution, and ultimately it can be cervical cancer during pregnancy suture associated with several diferent types of tumors [20].

Breast biopsy. It is preferable to use · CA —During pregnancy this marker is Core parazitii site oficial biopsy rather than incisional biopsy increased because it is produced in the decidual cells because it cervical cancer during pregnancy be performed under local anesthesia and amnion [21]. Surgery avoid damaging the uterus by theVeres needle or by the trocar; Both surgery and anesthesia are safe in - The duration of the cervical cancer during pregnancy should be less pregnancy, the risk of fetal distress occurring only cervical cancer during pregnancy than 90 minutes; the event of major complications such as peritonitis, - Pneumoperitoneum will have a maximum or hemorrhagic shock [11, 13].

The main operating pressure of 10 to 13 mmHg; complication that can occur after surgery is preterm - Intervention should be performed by an birth due to premature labor, which can occur due to experienced surgeon; uterine manipulation [12].

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After weeks of gestation, it is preferable Regarding cervical cancer during pregnancy teratogenic risk of anesthetics to use midline laparotomy rather than laparoscopy, due cervical cancer during pregnancy seems that most anesthetics are safe throughout to the increasing size of the uterus [1].

However it should be considered the maternal functional changes which are occurring Regarding breast cancer we can safely during pregnancy increased consumption of O2, the practice modified radical mastectomy or conservative decrease of residual pulmonary capacity, hypovolemic surgery lumpectomy with axillary lymphadenectomy syndrome, the inferior vena cava syndrome, etc.

SLNB homeostasis to avoid fetal complications due to has become a good alternative to axillary maternal hypotension[1].

Colposcopic assessment and management of the HPV infection in pregnancy

The role of bilateral pelvic lymphadenectomy is diagnostic not therapeutic, II. Chemotherapy because it seeks to establish the degree of extension of the disease and to achieve a more accurate Most clinical trials about fetuses exposed to staging[2].

Almost all chemotherapeutics are crossing differential diagnosis of adnexal tumors has to be through the placental barrier using passive diffusion, done, because the surgical risks are minimized using depending on liposolubility, polarity and molecular this technique. Goidescu have the possibility of full regeneration. Between the 10th day and the 9th week taxanes are crossing the placental barrier in small after conception, the organogenesis cervical cancer during pregnancy, and quantities[31].

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Even if A. Alkylating agents are acting directly on organogenesis is completed, there is an increased cellular DNA, preventing cell replication.

Cervical Cancer Awareness Week

After 14 weeks of pregnancy, neoadjuvant to reduce the effect of ovarian stimulation and are chemotherapy may come into question, the maintained at least cervical cancer during pregnancy weeks after completing the teratogenic risk being smaller [11].

Even after this treatment [33]. Platinum-based antineoplastic drugs- the metabolism,the excretion and their bioavailability, the mostly used group to treat gynecologic cancers.

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These platinum complexes react in Physiological changes in pregnancy that can vivo, binding to and causing crosslinking of DNA, affect the chemotherapy are : which ultimately triggers apoptosis [36]. Some studies system; show a slightly ototoxic effect causing bilateral · A slowing of the intestinal tract function reduction of hearing and ventriculomegaly, in children and consequently in the absorption of the born to mothers who carried out chemotherapy using chemotherapeutics this substance in pregnancy and for cervical cancer during pregnancy reason · A decrease in serum albumin which cervical cancer during pregnancy Carboplatin is most commonly used [11].

Usually the dosages of chemotherapy used · Oxaliplatin - is used for treatment of during pregnancy are similar to those applied to non- colorectal cancer and advanced ovarian cancer. Anthracyclines are topoisomerase dysfunction, which leads to a decreased fertility cervical cancer during pregnancy. Hormonal therapy Cyclophosphamide. Cardonick et al, concluded in a study, that it is preferable to use Doxorubicin Tamoxifen is contraindicated throughout versus Epirubicin, due to more helmintox 250 mg kaufen cervical cancer during pregnancy effects pregnancy, because of the increased risk of fetal of the Epirubicin[28], but other studies do not support malformations craniofacial and urogenital these findings [38].

Fetal cardiotoxicity due to in utero malformations [13, 40]. Monoclonal antibodies subsequent studies, which assessed in utero cardiac function but also the cervical cancer during pregnancy cardiac function of Trastuzumab crosses the placenta in the newborns [39]. Taxanes: Paclitaxel or Docetaxel are which leads to oligoamnios and anhydramnios[41]. It seems that acts on VEGF, which passes through the placenta they do not cross the placental barrier and can be and has also a teratogenic effect, being known that used safely during pregnancy[36].

VEGF plays a key role in embryo-fetal development[1]. Adjuvant medication treatment of hematological malignancies and less in the treatment of gynecologic cancers, because it has A. Radiotherapy associated with low birth weight, fetal hormonal disorders, attention disorders in childhood and cerebral Radiotherapy and Brachytherapy of the palsy[11]. Granulocyte colony stimulating radiotherapy of the upper extremity of the body and factors Filgrastim® and Erythropoietin may be the limbs is possible in the second quarter, especially used without reservation[11].